Open AccessHuman Leukocyte Transmigration Across Galα(1,3)Gal-Negative Porcine Endothelium Is Regulated by Human CD18 and CD99
Author(s) -
Mårten K J Schneider,
Maddalena Ghielmetti,
Daniel M. Rhyner,
Maria Antsiferova,
Jörg Dieter Seebach
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318195fb8d
Subject(s) - xenotransplantation , peripheral blood mononuclear cell , microbiology and biotechnology , cell adhesion , receptor , biology , cell adhesion molecule , immunology , cell , in vitro , transplantation , medicine , biochemistry
In pig-to-human xenotransplantation cross-species receptor interactions mediate cellular infiltration and rejection of porcine grafts. However, the mechanisms responsible for recruitment of human leukocyte subsets across porcine endothelial cells (EC) remain largely unknown. Here, we investigated the role of CD99, CD18, and Galalpha(1,3)Gal (Gal) in this process.