Open AccessGalectin-3-Mediated Xenoactivation of Human Monocytes
Author(s) -
Allen Greenwald,
Rongyu Jin,
Thomas K. Waddell
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318191e6b4
Subject(s) - monocyte , galectin 3 , xenotransplantation , microbiology and biotechnology , paracrine signalling , autocrine signalling , galectin , flow cytometry , chemistry , galectin 1 , biology , transplantation , immunology , receptor , medicine , biochemistry
Delayed xenograft rejection (DXR) remains a roadblock to successful xenotransplantation. A feature of DXR is early recruitment of monocytes to the xenograft. Naïve human monocytes can recognize and adhere to unstimulated porcine aortic endothelial cells (PAEC) more than human aortic endothelial cells, partly due to endothelial expression of the xenoantigen galactose-alpha(1,3)galactose-beta(1,4)GlcNAc-R (alpha-gal). Previous work from our laboratory has implicated galectin-3 as a candidate molecule on monocytes involved in initial recognition and adhesion of human monocytes to PAEC.