Open AccessRepetitive Gastric Aspiration Leads to Augmented Indirect Allorecognition After Lung Transplantation in Miniature Swine
Author(s) -
Andrew J. Meltzer,
Matthew J. Weiss,
Gregory Veillette,
H. Sahara,
Choo Ng,
Meghan E. Cochrane,
Stuart L. Houser,
David H. Sachs,
Bruce R. Rosengard,
Joren C. Madsen,
John C. Wain,
James S. Allan
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318190afe6
Subject(s) - medicine , transplantation , lung , lung transplantation , allorecognition , surgery , gastroenterology , pathology , major histocompatibility complex , immunology , antigen
Lung transplant recipients with documented gastroesophageal reflux disease (GERD) are at increased risk for graft dysfunction. Here, we present the first large-animal model of gastric aspiration after allogeneic lung transplantation and some preliminary data demonstrating the effect of chronic aspiration on the direct and indirect pathways of allorecognition.