Open AccessDonor-Specific Antibodies Against HLA, MICA, and GSTT1 in Patients with Allograft Rejection and C4d Deposition in Renal Biopsies
Author(s) -
Antonia Álvarez-Márquez,
Isabel Aguilera,
M.A. Gentil,
L. José,
Gabriel Bernal,
Jorge Fernández Alonso,
María José Acevedo,
Virginia Cabello,
I Wichmann,
María Francisca GonzálezEscribano,
Antonio NúñezRoldán
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31818bd790
Subject(s) - antibody , human leukocyte antigen , medicine , immunology , transplantation , antigen , panel reactive antibody , kidney transplantation , kidney , peritubular capillaries
Production of antibodies against donor-specific antigens is one of the central mechanisms of allograft rejection. This antibody-mediated rejection (AMR) is evidenced by the presence of circulating donor-specific antibodies and deposition of complement component C4d on renal endothelium. Although anti-human leukocyte antigen (HLA) antibodies account for a high proportion of AMR, in many cases anti-HLA antibodies cannot be demonstrated. In liver transplant, antibodies against glutathione-S-transferase T1 (GSTT1) expressed on the graft may induce an antibody response leading to a severe graft dysfunction. In addition, presence of antibodies against major-histocompatibility-complex class I chain-related gene A (MICA) has been associated with a poor graft survival in kidney transplantation.