Open AccessSusceptibility of Human Mesenchymal Stem Cells to Tacrolimus, Mycophenolic Acid, and Rapamycin
Author(s) -
Martin J. Hoogduijn,
Meindert J. Crop,
Sander S. Korevaar,
Annemiek M.A. Peeters,
Marco Eijken,
Lex P.W.M. Maat,
A. H. M. M. Balk,
Willem Weimar,
Carla C. Baan
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31818aa536
Subject(s) - tacrolimus , mesenchymal stem cell , mycophenolic acid , sirolimus , calcineurin , pharmacology , mycophenolate , transplantation , cancer research , immunosuppressive drug , biology , medicine , microbiology and biotechnology
Mesenchymal stem cells (MSC) have multilineage differentiation and immunomodulatory capacities and are potentially useful for therapeutic applications, such as tissue regeneration and control of alloreactivity. MSC are present in most tissues including the transplantable organs. It is therefore unavoidable that MSC will be exposed to immunosuppressive drugs in a clinical transplantation setting. The molecular targets of these drugs are expressed in MSC, but the effect of their inhibition on MSC functioning is unknown.