Open AccessPosttransplant Ischemia-Reperfusion Injury In Transplanted Heart Is Prevented By A Minibody to the Fifth Component of Complement
Author(s) -
Mariano Ferraresso,
Paolo Macor,
Marialuisa Valente,
Mila Della Barbera,
Fabio D’Amelio,
Maria Orietta Borghi,
Elena Raschi,
Paolo Durigutto,
Pier Luigi Meroni,
Francesco Tedesco
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31818a68e2
Subject(s) - complement system , medicine , necrosis , transplantation , ischemia , heart transplantation , allotransplantation , pathology , pharmacology , immunology , antibody
Complement activation has been implicated in the development of posttransplant ischemia-reperfusion (I/R) which is responsible for the delayed function of 20% to 30% of grafts. C5a and the terminal complement complex (TCC) are the complement activation products mainly involved in tissue injury caused by I/R.