Open AccessReduced Intensity Conditioning for Allogeneic Hematopoietic Stem-Cell Transplant Determines the Kinetics of Acute Graft-Versus-Host Disease
Author(s) -
Brie E. Turner,
Melinda E. Kambouris,
Laura J. Sinfield,
Janusz Lange,
Austin Burns,
Rohan Lourie,
Kerry Atkinson,
Derek N. J. Hart,
David J. Munster,
Alison Rice
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181874787
Subject(s) - immunology , hematopoietic stem cell transplantation , minor histocompatibility antigen , graft versus host disease , transplantation , haematopoiesis , medicine , histocompatibility , cytokine , tumor necrosis factor alpha , stem cell , major histocompatibility complex , immune system , biology , antigen , human leukocyte antigen , genetics
Preparative myeloablative conditioning regimens for allogeneic hematopoietic stem-cell transplantation (HSCT) may control malignancy and facilitate engraftment but also contribute to transplant related mortality, cytokine release, and acute graft-versus-host disease (GVHD). Reduced intensity conditioning (RIC) regimens have decreased transplant related mortality but the incidence of acute GVHD, while delayed, remains unchanged. There are currently no in vivo allogeneic models of RIC HSCT, limiting studies into the mechanism behind RIC-associated GVHD.