Open AccessReciprocal Activation Between CD4+ T Cells and Kupffer Cells During Hepatic Ischemia-Reperfusion
Author(s) -
Marc Hanschen,
Stefan Zahler,
Fritz Krombach,
Andrej Khandoga
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181821aa7
Subject(s) - kupffer cell , tumor necrosis factor alpha , t cell , biology , flow cytometry , microbiology and biotechnology , chemistry , endocrinology , immunology , immune system
Mechanisms mediating CD4+ T-cell recruitment during alloantigen-independent hepatic ischemia-reperfusion (I/R) remain not fully understood. We hypothesized that Kupffer cells activate CD4+ T-cells in the postischemic liver, by the release of free oxygen radicals and cytokines.