Open AccessRandomization is Essential for Progress in Transplant Medicine
Author(s) -
Colin Baigent,
Jonathan Emberson
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31817d4f14
Subject(s) - randomization , randomized controlled trial , medicine , intensive care medicine
Improvements in immunosuppressive regimens are likely to be moderate in size. Therefore, studies to detect them reliably require a guarantee of small biases (so randomization is essential) and small random errors. Even after adjustment, nonrandomized studies may have large biases, so are not a suitable alternative to large randomized trials.