Open AccessRegulation of Human Interleukin 14 Transcription In Vitro and In Vivo After Renal Transplantation
Author(s) -
Nicolae Leca,
M. R. Laftavi,
Long Shen,
Kristin Matteson,
Julian L. Ambrus,
O. Pankewycz
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31817c6380
Subject(s) - transplantation , in vivo , biology , immunology , immune system , in vitro , interleukin , interleukin 2 , interleukin 15 , cytokine , medicine , biochemistry , microbiology and biotechnology
Alloantibodies and B lymphocytes are felt to contribute in increasingly important ways to the pathogenesis of both acute and chronic allograft injury. The mechanisms that lead to the formation of posttransplant alloantibodies despite immunosuppressive therapy have not been fully elucidated. Interleukin 14 (IL-14) or high molecular weight B cell growth factor secreted by activated T and B cells and follicular dendritic cells promotes B cell growth, survival and memory, and antibody production. The potential role of IL-14 in human transplantation has not been examined.