Open AccessSTAT3: An Important Regulator of Multiple Cytokine Functions
Author(s) -
Stanislaw M. Stepkowski,
Wenhao Chen,
Jeremy A. Ross,
Zsuzsangy,
Robert A. Kirken
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181739d25
Subject(s) - stat3 , regulator , microbiology and biotechnology , biology , acquired immune system , cytokine , stat , transcription factor , immunology , janus kinase , immune system , signal transduction , transplantation , tyrosine kinase , medicine , genetics , gene
Maintaining T cell homeostasis is critical for normal immune response. Three sequential signals activate T cells, with signal 3 delivered by multiple cytokines that regulate cell proliferation, differentiation, and survival/death. Cytokines binding to their receptors engages two key molecular families, namely, Janus tyrosine kinases (Jaks) and signal transducers and activators of transcription (Stats). Among Stats, Stat3 is involved in the generation of T helper 17 (Th17) cells, regulation of dendritic cells, and acute inflammatory response. These aspects of Stat3 function are important for transplantation. We discuss Stat3's role in innate and adaptive immunity as well as its potential for therapeutic intervention.