Repression of BK Virus Infection of Human Renal Proximal Tubular Epithelial Cells by Pravastatin | Zendy

Takahito Moriyama | Zendy; Andrey Sorokin | Zendy

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Repression of BK Virus Infection of Human Renal Proximal Tubular Epithelial Cells by Pravastatin

Author(s) -

Takahito Moriyama,

Andrey Sorokin

Publication year - 2008

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e31816c4ec5

Subject(s) - pravastatin , bk virus , internalization , endocytosis , biology , virology , immunology , kidney , kidney transplantation , endocrinology , cell , cholesterol , genetics

BK virus (BKV), a human polyomavirus, causes BKV nephritis, which often leads to graft loss after renal transplantation. Currently, the only efficient therapy against BKV nephritis seems to be a reduction or change of immunosuppressive agents, but this may increase the inherent risk of rejection. Here, we report the ability of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitor (statin), which is routinely used to treat hypercholesterolemia, to repress BKV entry pathways in human renal proximal tubular epithelial cells (HRPTEC) and, correspondently, prevent BKV infection.

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