Open AccessLymphoid Tissue Formation in Allografts: Innocent Until Proven Guilty
Author(s) -
Reza Motallebzadeh,
Eleanor M. Bolton,
Gavin J. Pettigrew
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318162d2d0
Subject(s) - lymphatic system , immune system , immunology , inflammation , function (biology) , medicine , biology , microbiology and biotechnology
Tertiary lymphoid organs (TLOs) are lymphoid-like structures commonly found at sites of chronic inflammation. Commonly associated with autoimmune responses, they have recently been described within organ allografts. Although TLOs are similar structurally to secondary lymphoid organs, their function remains largely unknown. In this review, we discuss how immune responses within TLOs may influence graft survival.