Open AccessPretransplant Donor-Specific and Non-Specific Immune Parameters Associated With Early Acute Rejection
Author(s) -
Nancy L. Reinsmoen,
Karen M. Cornett,
Robert Kloehn,
Angela D. Burnette,
Lois McHugh,
Barbara K. Flewellen,
Arthur J. Matas,
Kay Savik
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181612ead
Subject(s) - medicine , immunosuppression , creatinine , biopsy , immune system , human leukocyte antigen , immunology , elispot , prednisone , gastroenterology , antibody , antigen , t cell
New immunosuppression protocols have resulted in decreased rates of biopsy-proven acute rejection; however, it is unclear whether recipients without biopsy-proven acute rejection are still at risk for immune complication and chronic allograft dysfunction. The aim of our studies was to determine whether pretransplant immune parameters were associated with posttransplant early acute rejection, unstable creatinine courses, and poor graft outcome.