Open AccessImpact of Red Blood Cells on Function and Metabolism of Porcine Deceased Donor Kidneys During Normothermic Machine Perfusion
Author(s) -
Leonie H Venema,
L. Leonie van Leeuwen,
Rene A. Posma,
Harry van Goor,
Rutger J. Ploeg,
Patrick Hannaert,
Thierry Hauet,
Thomas Minor,
Henri G. D. Leuvenink
Publication year - 2022
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003940
Subject(s) - machine perfusion , perfusion , metabolism , transplantation , renal function , kidney , creatinine , blood substitute , ischemia , chemistry , red blood cell , cold storage , medicine , andrology , urology , biochemistry , biology , hemoglobin , liver transplantation , horticulture
Normothermic machine perfusion (NMP) protocols using blood-based solutions are commonly used in the assessment of kidneys before transplantation. This procedure is, nevertheless, limited by blood availability and warrants the search for alternatives. We compared a blood-based solution with a serum-like preservation solution (Aqix) enriched with colloids with and without red blood cells (RBCs).