Open AccessA 2-fold Approach to Polyoma Virus (BK) Nephropathy in Kidney Transplants: Distinguishing Direct Virus Effects From Cognate T Cell–mediated Inflammation
Author(s) -
Philip F. Halloran,
Katelynn S. MadillThomsen,
Georg A. Böhmig,
Marek Myślak,
Gaurav Gupta,
Dhiren Kumar,
Ondřej Viklický,
Agnieszka PerkowskaPtasińska,
Konrad S. Famulski
Publication year - 2021
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003884
Subject(s) - inflammation , t cell , pathology , nephropathy , immunology , medicine , immune system , endocrinology , diabetes mellitus
BK nephropathy (BKN) in kidney transplants diagnosed by histology is challenging because it involves damage from both virus activity and cognate T cell-mediated inflammation, directed against alloantigens (rejection) or viral antigens. The present study of indication biopsies from the Integrated Diagnostic System in the International Collaborative Microarray Study Extension study measured major capsid viral protein 2 (VP2) mRNA to assess virus activity and a T cell-mediated rejection (TCMR) classifier to assess cognate T cell-mediated inflammation.