Open AccessControlled Oxygenated Rewarming Compensates for Cold Storage–induced Dysfunction in Kidney Grafts
Author(s) -
Charlotte von Horn,
Hristo Zlatev,
Moritz Kaths,
Andreas Paul,
Thomas Minor
Publication year - 2021
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003854
Subject(s) - machine perfusion , cold storage , perfusion , medicine , transplantation , kidney , renal function , ischemia , viaspan , kidney transplantation , urology , chemistry , surgery , biology , liver transplantation , horticulture
Normothermic machine perfusion (NMP) provides a promising strategy for preservation and conditioning of marginal organ grafts. However, at present, high logistic effort limits normothermic renal perfusion to a short, postponed machine perfusion at site of the recipient transplant center. Thus, organ preservation during transportation still takes place under hypothermic conditions, leading to significantly reduced efficacy of NMP. Recently, it was shown that gentle and controlled warming up of cold stored kidneys compensates for hypothermic induced damage in comparison to end ischemic NMP. This study aims to compare controlled oxygenated rewarming (COR) with continuous upfront normothermic perfusion in a porcine model of transplantation.