Open AccessAutologous Hematopoietic Stem Cell Transplantation for Liver Transplant Recipients With Recurrent Primary Sclerosing Cholangitis: A Pilot Study
Author(s) -
Andrzej Chruscinski,
S. Juvet,
Sajad Moshkelgosha,
Eberhard L. Renner,
Leslie Lilly,
Nazia Selzner,
Christopher Bredeson,
David Grant,
Oyedele Adeyi,
Sandra E. Fischer,
Anthony J. Demetris,
Jianhua Zhang,
Maor Epstein,
Meaghan Macarthur,
Anne Marie Clement,
Korosh Khalili,
David Allan,
Sultan Altouri,
Isabelle BenceBruckler,
Mark S. Cattral,
Jill Fulcher,
Zita Galvin,
Anand Ghanekar,
Paul D. Greig,
Lothar Huebsch,
Atul Humar,
Andrea Kew,
Natasha Kekre,
Tae Kyoung Kim,
Sheryl McDiarmid,
Lisa Martin,
Ian McGilvray,
Mitchell Sabloff,
Gonzalo Sapisochín,
Markus Selzner,
Robert Smith,
Kathryn Tinckham,
Tae Joon Yi,
Gary Levy,
Harold L. Atkins
Publication year - 2021
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003829
Subject(s) - medicine , primary sclerosing cholangitis , hematopoietic stem cell transplantation , stem cell , transplantation , haematopoiesis , liver transplantation , pathology , biology , disease , genetics
Primary sclerosing cholangitis (PSC) is an indication for liver transplantation, but recurrence after liver transplantation is associated with poor outcomes often requiring repeat transplantation. We investigated whether autologous hematopoietic stem cell transplantation (aHSCT) could be used to stop progression of recurrent PSC and promote operational tolerance.