Open AccessEx Vivo Expanded Donor Alloreactive Regulatory T Cells Lose Immunoregulatory, Proliferation, and Antiapoptotic Markers After Infusion Into ATG-lymphodepleted, Nonhuman Primate Heart Allograft Recipients
Author(s) -
Mohamed Ezzelarab,
Hong Zhang,
Kazuki Sasaki,
Л. Лу,
Alan F. Zahorchak,
Dirk J. van der Windt,
Helong Dai,
Angélica Pérez-Gutiérrez,
Jay K. Bhama,
Angus W. Thomson
Publication year - 2021
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003617
Subject(s) - foxp3 , immunology , transplantation , adoptive cell transfer , t cell , biology , flow cytometry , regulatory t cell , ex vivo , heart transplantation , in vivo , medicine , immune system , il 2 receptor , microbiology and biotechnology
Regulatory T cell (Treg) therapy is a promising approach to amelioration of allograft rejection and promotion of organ transplant tolerance. However, the fate of infused Treg, and how this relates to their therapeutic efficacy using different immunosuppressive regimens is poorly understood. Our aim was to analyze the tissue distribution, persistence, replicative activity and phenotypic stability of autologous, donor antigen alloreactive Treg (darTreg) in anti-thymocyte globulin (ATG)-lymphodepleted, heart-allografted cynomolgus monkeys.