Open AccessOverexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model
Author(s) -
Simoemska,
François Daubeuf,
Adeline Obrecht,
Dominique IsraëlBiet,
M. Stern,
Romain Kessler,
Antoine Roux,
Reza Tavakoli,
Pascal Villa,
Adrien Tissot,
Richard Danger,
Laurent L. Reber,
Eugénie Durand,
Aurore Foureau,
Sophie Brouard,
A. Magnan,
Nelly Frossard
Publication year - 2021
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003606
Subject(s) - proinflammatory cytokine , medicine , lung , bronchiolitis obliterans , lung transplantation , kinase , pathology , cancer research , immunology , inflammation , biology , microbiology and biotechnology
Chronic lung allograft dysfunction (CLAD) and its obstructive form, the obliterative bronchiolitis (OB), are the main long-term complications related to high mortality rate postlung transplantation. CLAD treatment lacks a significant success in survival. Here, we investigated a new strategy through inhibition of the proinflammatory mitogen- and stress-activated kinase 1 (MSK1) kinase.