Open AccessChronic Histologic Changes Are Present Regardless of HLA Mismatches: Evidence from HLA-Identical Living Donor Kidney Transplants
Author(s) -
Matthew R D'Costa,
Andrew Bentall,
Aleksandar Denic,
Carrie A. Schinstock,
Massini Merzkani,
Walter D. Park,
Margaret Ryan,
Mariam P. Alexander,
Byron H. Smith,
Manish J. Gandhi
Publication year - 2021
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003579
Subject(s) - medicine , immunosuppression , fibrosis , kidney disease , kidney transplantation , human leukocyte antigen , gastroenterology , cohort , transplantation , pathology , immunology , antigen
At 5 and 10 y after kidney transplantation, chronic histologic changes such as arteriolar hyalinosis and mesangial expansion are common; however, determining cause is difficult. We compared surveillance biopsies in living donor kidney transplants (LDKTx) from HLA-matched siblings (termed HLA-identical [HLA-ID]) with HLA non-ID to investigate which histologic changes were likely due to alloimmune injury and which were due to nonalloimmune injury.