Open AccessDesign, Analysis, and Pitfalls of Clinical Trials Using Ex Situ Liver Machine Perfusion: The International Liver Transplantation Society Consensus Guidelines
Author(s) -
Paulo N. Martins,
Michael Rizzari,
Davide Ghinolfi,
Ina Jochmans,
Magdy Attia,
Rajiv Jalan,
Peter Friend
Publication year - 2021
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003573
Subject(s) - liver transplantation , clinical trial , medicine , machine perfusion , randomization , context (archaeology) , transplantation , clinical endpoint , protocol (science) , randomized controlled trial , intensive care medicine , medical physics , surgery , pathology , alternative medicine , paleontology , biology
Recent trials in liver machine perfusion (MP) have revealed unique challenges beyond those seen in most clinical studies. Correct trial design and interpretation of data are essential to avoid drawing conclusions that may compromise patient safety and increase costs.