Open AccessMurine Cytomegalovirus–induced Complement-fixing Antibodies Deposit in Murine Renal Allografts During Acute Rejection
Author(s) -
Ute Saunders,
Mao Li,
Srinivasa Rao Boddeda,
Sonya Maher,
Jessica Ghere,
Irina Kaptsan,
Ravi Dhital,
Victoria M. Velazquez,
Lingling Guo,
Bin Chen,
Qiang Zeng,
Trenton R. Schoeb,
Rachel E. Cianciolo,
Masako Shimamura
Publication year - 2021
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003548
Subject(s) - antibody , immunology , cytomegalovirus , ganciclovir , transplantation , immunostaining , immune system , betaherpesvirinae , kidney , immunoglobulin g , human cytomegalovirus , medicine , virology , herpesviridae , virus , viral disease , immunohistochemistry
Human cytomegalovirus (CMV) infection is associated with renal allograft dysfunction and loss, particularly in combination with acute rejection. Emerging literature suggests that non-HLA antibodies may contribute to antibody-mediated rejection, but pathogen-induced antibodies have not been investigated in this context. This study examines the presence of CMV-induced antibodies in murine CMV (MCMV)-infected renal allografts during acute rejection.