Open AccessLongitudinal Analysis of the T-cell Receptor Repertoire in Graft-infiltrating Lymphocytes Following Hand Transplantation
Author(s) -
Joseph Y. Kim,
Zhengdeng Lei,
Mark MaienscheinCline,
George E. Chlipala,
Arumugam Balamurugan,
Sue V. McDiarmid,
Kodi Azari,
Otto O. Yang
Publication year - 2021
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003535
Subject(s) - t cell receptor , transplantation , immunology , biology , t lymphocyte , clonal deletion , cellular immunity , immunity , immune system , lymphocyte , t cell , medicine
T lymphocyte-mediated acute rejection is a significant complication following solid organ transplantation. Standard methods of monitoring for acute rejection rely on assessing histological tissue damage but do not define the immunopathogenesis. Additionally, current therapies for rejection broadly blunt cellular immunity, creating a high risk for opportunistic infections. There is, therefore, a need to better understand the process of acute cellular rejection to help develop improved prognostic tests and narrowly targeted therapies.