Open AccessHLA and AB0 Polymorphisms May Influence SARS-CoV-2 Infection and COVID-19 Severity
Author(s) -
Antonio Amoroso,
Paola Mapelli,
Francesca Vespasiano,
Antonino Bella,
Stefania Bellino,
Francesca Puoti,
Silvia Alizzi,
Tiziana Vaisitti,
Stefano Boros,
Paolo Grossi,
Silvia Trapani,
Letizia Lombardini,
Patrizio Pezzotti,
Silvia Deaglio,
Silvio Brusaferro,
Massimo Cardillo
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003507
Subject(s) - medicine , covid-19 , cohort , population , human leukocyte antigen , incidence (geometry) , cumulative incidence , immunology , cohort study , retrospective cohort study , virology , disease , infectious disease (medical specialty) , antigen , environmental health , physics , optics
SARS-CoV-2 infection is heterogeneous in clinical presentation and disease evolution. To investigate whether immune response to the virus can be influenced by genetic factors, we compared HLA and AB0 frequencies in organ transplant recipients and waitlisted patients according to presence or absence of SARS-CoV-2 infection.