Open AccessAnti-ICOS mAb Targets Pathogenic IL-17A-expressing Cells in Canine Model of Chronic GVHD
Author(s) -
Maura H. Parker,
Diane Stone,
Kraig Abrams,
Melissa M. Johnson,
Noa Granot,
Rainer Storb
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003489
Subject(s) - cd8 , immunology , granzyme b , granzyme , medicine , peripheral blood mononuclear cell , pathogenesis , bone marrow , graft versus host disease , monoclonal antibody , cytotoxic t cell , immune system , flow cytometry , antibody , disease , biology , pathology , perforin , biochemistry , in vitro
Chronic graft-versus-host disease (GVHD) is a significant cause of morbidity and mortality in transplant patients. We have previously shown that 3 doses of an anti-inducible costimulator (ICOS) mAb transiently ameliorated symptoms and extended survival of dogs affected by chronic GVHD over that of control dogs. The purpose of this study was to specifically correlate changes in T-cell populations in the peripheral blood with anti-ICOS treatment and chronic GVHD progression and regression to reach a better understanding of the mechanism of the disease and prioritize future studies.