Open AccessMonth-long Respiratory Support by a Wearable Pumping Artificial Lung in an Ovine Model
Author(s) -
Ryan A. Orizondo,
Katelin S. Omecinski,
Alexandra May,
Vishaal Dhamotharan,
Brian J. Frankowski,
Greg W. Burgreen,
SangHo Ye,
Ergin Koçyıldırım,
Pablo G. Sánchez,
Jonathan D’Cunha,
William R. Wagner,
William J. Federspiel
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003481
Subject(s) - artificial lung , extracorporeal , medicine , life support , lung , anesthesia , biomedical engineering , extracorporeal membrane oxygenation , lung transplantation , surgery , intensive care medicine
A wearable artificial lung could improve lung transplantation outcomes by easing implementation of physical rehabilitation during long-term pretransplant respiratory support. The Modular Extracorporeal Lung Assist System (ModELAS) is a compact pumping artificial lung currently under development. This study evaluated the long-term in vivo performance of the ModELAS during venovenous support in awake sheep. Feedback from early trials and computational fluid dynamic analysis guided device design optimization along the way.