Open AccessDNA-PKcs Inhibition Extends Allogeneic Skin Graft Survival
Author(s) -
David K. Harrison,
Zachary Waldrip,
Lyle Burdine,
Sara C. Shalin,
Marie Schluterman Burdine
Publication year - 2021
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003442
Subject(s) - dna pkcs , immune system , cd19 , transplantation , cancer research , immunology , biology , immunosuppression , protein kinase a , kinase , microbiology and biotechnology , medicine
Organ transplantation is life-saving and continued investigations into immunologic mechanisms that drive organ rejection are needed to improve immunosuppression therapies and prevent graft failure. DNA-dependent protein kinase catalytic subunit, DNA dependent-protein kinase catalytic subunit (DNA-PKcs), is a critical component of both the cellular and humoral immune responses. In this study, we investigate the contribution of DNA-PKcs to allogeneic skin graft rejection to potentially highlight a novel strategy for inhibiting transplant rejection.