Open AccessBET Protein Inhibition Prolongs Cardiac Transplant Survival via Enhanced Myocardial Autophagy
Author(s) -
Juntao Chen,
Xudong Miao,
Chen Liu,
Baoqing Liu,
Xiaoying Wu,
Dan Kong,
Qiming Sun,
Weihua Gong
Publication year - 2020
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003319
Subject(s) - autophagy , ulk1 , transplantation , cancer research , medicine , heart transplantation , protein kinase a , kinase , immunology , pharmacology , biology , apoptosis , microbiology and biotechnology , biochemistry , ampk
Graft rejection continues to be a major barrier to long-term engraftment after transplantation. Autophagy plays an important role in cardiac injury pathogenesis. The bromodomain and extraterminal protein inhibitor (S)-tert-butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (JQ1) inhibits inflammatory responses. However, the beneficial effect of JQ1 on transplant and the potential role of autophagy in the protective effect of graft survival are yet to be investigated.