Open AccessComplement 5 Inhibition Ameliorates Hepatic Ischemia/reperfusion Injury in Mice, Dominantly via the C5a-mediated Cascade
Author(s) -
Jiro Kusakabe,
Koichiro Hata,
Ichiro Tamaki,
Tetsuya Tajima,
Hidetaka Miyauchi,
Yi Wang,
Yermek Nigmet,
Yusuke Okamura,
Takumi Kubota,
Hirokazu Tanaka,
Tatsuaki Tsuruyama,
Shinji Üemoto
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003302
Subject(s) - reperfusion injury , c5a receptor , complement component 5 , complement system , pharmacology , liver transplantation , medicine , ischemia , transplantation , inflammation , immunology , antibody
Hepatic ischemia/reperfusion injury (IRI) is a serious complication in liver surgeries, including transplantation. Complement activation seems to be closely involved in hepatic IRI; however, no complement-targeted intervention has been clinically applied. We investigated the therapeutic potential of Complement 5 (C5)-targeted regulation in hepatic IRI.