Open AccessTransient-mixed Chimerism With Nonmyeloablative Conditioning Does Not Induce Liver Allograft Tolerance in Nonhuman Primates
Author(s) -
Sulemon Chaudhry,
Yojiro Kato,
Joshua Weiner,
Paula AlonsoGuallart,
S. Baker,
David C. Woodland,
Jay H. Lefkowitch,
Raimon DuranStruuck,
Hugo Sondermeijer,
Jonah Zitsman,
Mallory L. Sears,
Anette Wu,
Brian Karolewski,
Philipp J. Houck,
Mercedes Martínez,
Tomoaki Kato,
Megan Sykes,
Adam Griesemer
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003263
Subject(s) - immunosuppression , immune tolerance , liver transplantation , immunology , transplantation chimera , medicine , cd8 , kidney , transplantation , immune system , kidney transplantation , bone marrow , biology , haematopoiesis , stem cell , genetics , hematopoietic cell
Although short-term outcomes for liver transplantation have improved, patient and graft survival are limited by infection, cancer, and other complications of immunosuppression. Rapid induction of tolerance after liver transplantation would decrease these complications, improving survival and quality of life. Tolerance to kidneys, but not thoracic organs or islets, has been achieved in nonhuman primates and humans through the induction of transient donor chimerism. Since the liver is considered to be tolerogenic, we tested the hypothesis that the renal transplant transient chimerism protocol would induce liver tolerance.