Open AccessAngiotensin II Type-1 Receptor Antibodies Are Associated With Active Allograft Dysfunction Following Pediatric Liver Transplantation
Author(s) -
Laura J. Wozniak,
Michelle J. Hickey,
Alvin P. Chan,
Robert S. Venick,
Douglas G. Farmer,
Ronald W. Busuttil,
Elaine F. Reed,
Sue V. McDiarmid
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003206
Subject(s) - medicine , transplantation , cohort , antibody , angiotensin ii , gastroenterology , liver transplantation , immunology , receptor
Angiotensin II type-1 receptor (AT1R) antibodies have been associated with rejection and allograft loss in solid organ transplantation and may act synergistically with HLA donor-specific antibodies (DSA). Our aims were to assess the prevalence of AT1R antibodies and determine if they were associated with allograft dysfunction in pediatric liver transplant recipients.