Open AccessPeripheral Donor-specific Antibodies Are Associated With Histology and Cellular Subtypes in Protocol Liver Biopsies of Pediatric Recipients
Author(s) -
Vladimir L. Cousin,
AnneLaure Rougemont,
Laura RubbiaBrandt,
Barbara E. Wildhaber,
Jean Villard,
Sylvie FerrariLacraz,
Valérie Anne Mclin
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003099
Subject(s) - fibrosis , inflammation , cd68 , pathology , cd20 , foxp3 , immunostaining , cd8 , liver transplantation , medicine , cd3 , immunophenotyping , transplantation , immunology , immune system , biology , immunohistochemistry , antigen
The cellular infiltrate in protocol liver biopsies (PB) following pediatric liver transplantation remains mostly uncharacterized, yet there is increasing concern about the role of inflammation and fibrosis in long-term liver allografts. We aimed to define cell types in PB and to analyze their relationship with donor-specific antibodies (DSA) and histological phenotype.