Open AccessTargeting Calcium Release–activated Calcium Channel Is Not Sufficient to Prevent Rejection in Nonhuman Primate Kidney Transplantation
Author(s) -
Jean Kwun,
Brian Ezekian,
Miriam Manook,
Jae Berm Park,
Janghoon Yoon,
Kyle Freischlag,
Mingqing Song,
Alton B. Farris,
Joanne SloanLancaster,
Caroline Fortier,
Patricia E. Rao,
Stuart J. Knechtle
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003078
Subject(s) - tacrolimus , calcineurin , medicine , transplantation , nephrotoxicity , pharmacology , ciclosporin , kidney transplantation , kidney , transplant rejection , immunosuppressive drug , urology
Calcineurin inhibitors successfully control rejection of transplanted organs but also cause nephrotoxicity. This study, using a rhesus monkey renal transplantation model, sought to determine the applicability of a new immunomodulatory drug inhibiting the store-operated calcium release-activated calcium channel of lymphocytes to control transplant rejection without nephrotoxicity.