Open AccessMesenchymal Stromal Cells in Solid Organ Transplantation
Author(s) -
Morgan Vandermeulen,
Pauline Erpicum,
Laurent Weekers,
Alexandra Briquet,
Chantal Lechanteur,
Olivier Detry,
Yves Béguin,
François Jouret
Publication year - 2020
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003077
Subject(s) - mesenchymal stem cell , transplantation , medicine , clinical trial , cell therapy , stromal cell , organ transplantation , immune system , regenerative medicine , bioinformatics , cell , immunology , pathology , surgery , biology , genetics
Over the past decade, the clinical application of mesenchymal stromal cells (MSCs) has generated growing enthusiasm as an innovative cell-based approach in solid organ transplantation (SOT). These expectations arise from a significant number of both transplant- and non-transplant-related experimental studies investigating the complex anti-inflammatory, immunomodulatory, and tissue-repair properties of MSCs. Promising preclinical results have prompted clinical trials using MSC-based therapy in SOT. In the present review, the general properties of MSCs are summarized, with a particular emphasis on MSC-mediated impact on the immune system and in the ischemic conditioning strategy. Next, we chronologically detail all clinical trials using MSCs in the field of SOT. Finally, we envision the challenges and perspectives of MSC-based cell therapy in SOT.