Open AccessLiposomal Delivery Improves the Efficacy of Prednisolone to Attenuate Renal Inflammation in a Mouse Model of Acute Renal Allograft Rejection
Author(s) -
Carla M. A. van Alem,
Martina Schmidbauer,
Song Rong,
Katja Derlin,
Jessica Schmitz,
Jan Hinrich Bräsen,
Anja Thorenz,
Rongjun Chen,
Jurjen M. Ruben,
Elizabeth M. Winter,
Maaike Schilperoort,
Sander Kooijman,
Reshma Lalai,
Josbert M. Metselaar,
Christian Klemann,
Martin Meier,
Cees van Kooten,
Faikah Gueler,
Joris I. Rotmans
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003060
Subject(s) - medicine , prednisolone , urology , perfusion , transplantation , kidney , kidney transplantation , inflammation , immunology , pharmacology
Systemic exposure to high-dose corticosteroids effectively combats acute rejection after kidney transplantation, but at the cost of substantial side effects. In this study, a murine acute renal allograft rejection model was used to investigate whether liposomal-encapsulated prednisolone (LP) facilitates local exposure to enhance its therapeutic effect.