Open AccessDSA Are Associated With More Graft Injury, More Fibrosis, and Upregulation of Rejection-associated Transcripts in Subclinical Rejection
Author(s) -
Anne Höfer,
Danny Jonigk,
Björn Hartleben,
Murielle Verboom,
Michael Hallensleben,
Stefan G. Hübscher,
Michael P. Manns,
Elmar Jaeckel,
Richard Taubert
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003034
Subject(s) - subclinical infection , downregulation and upregulation , fibrosis , medicine , inflammation , immune system , immunohistochemistry , transplantation , pathology , immunology , gene , biology , biochemistry
Subclinical T cell-mediated rejection (subTCMR) is commonly found after liver transplantation and has a good short-term prognosis, even when it is left untreated. Donor-specific antibodies (DSA) are putatively associated with a worse prognosis for recipient and graft after liver transplantation.