Open AccessTNFAIP8 Deficiency Exacerbates Acute Graft Versus Host Disease in a Murine Model of Allogeneic Hematopoietic Cell Transplantation
Author(s) -
Reena Kumari,
Senthilnathan Palaniyandi,
Ethan Strattan,
Timothy Huang,
Katharina Köhler,
Nashwan Jabbour,
Joanna C. Dalland,
Jing Du,
Melissa Kesler,
Youhai H. Chen,
Gerhard C. Hildebrandt
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003013
Subject(s) - hematopoietic cell , graft versus host disease , transplantation , hematopoietic stem cell transplantation , haematopoiesis , immunology , medicine , disease , host (biology) , biology , stem cell , microbiology and biotechnology , ecology
Gastrointestinal acute graft-versus-host disease (GVHD) occurring after allogeneic hematopoietic cell transplant is an allo-reactive T cell and inflammatory cytokine driven organ injury with epithelial apoptosis as 1 of its hallmark findings and is associated with significant mortality. Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8 or TIPE) acts as a negative mediator of apoptosis via inhibition of caspase-3 activation, promotes cell proliferation and Tipe deficiency is associated with increased inflammation.