Open AccessAnti-BAFF Treatment Interferes With Humoral Responses in a Model of Renal Transplantation in Rats
Author(s) -
Louisa Steines,
Helen Poth,
Antonia Schuster,
Edward K. Geissler,
Kerstin Amann,
Bernhard Banas,
Tobias Bergler
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002992
Subject(s) - b cell activating factor , immunology , germinal center , b cell , antibody , transplantation , flow cytometry , spleen , medicine , cd40 , biology , cytotoxic t cell , biochemistry , in vitro
B-cell-activating factor (BAFF) is associated with donor-specific antibodies (DSA) and poorer outcomes after renal transplantation (RTx). We examined the effects of anti-BAFF treatment on B cells, expression of costimulatory molecules and cytokines, germinal centers (GCs), and DSA formation in an RTx model in rats.