Open AccessLong-term Kinetics of Intragraft Gene Signatures in Renal Allograft Tolerance Induced by Transient Mixed Chimerism
Author(s) -
Masatoshi Matsunami,
Ivy A. Rosales,
Benjamin Adam,
Tetsu Oura,
Michael Mengel,
R. Neal Smith,
Hang Lee,
A. Benedict Cosimi,
Robert B. Colvin,
Tatsuo Kawai
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002911
Subject(s) - foxp3 , immunosuppression , kidney , gata3 , immunology , medicine , renal function , biology , endocrinology , immune system , gene , transcription factor , biochemistry
Renal allograft tolerance (TOL) has been successfully induced in nonhuman primates (NHPs) and humans through the induction of transient mixed chimerism. To elucidate the mechanisms of TOL, we compared local immunologic responses in renal allografts with those in T-cell-mediated rejection (TCMR) and chronic antibody-mediated rejection (CAMR) in NHPs.