Open AccessBilirubin Improves the Quality and Function of Hypothermic Preserved Islets by Its Antioxidative and Anti-inflammatory Effect
Author(s) -
Qing Yao,
Xue Jiang,
Zhiwei Huang,
Qing-Hua Lan,
Lifen Wang,
Rui Chen,
Xin-Ze Li,
Longfa Kou,
HeLin Xu,
YingZheng Zhao
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002882
Subject(s) - islet , oxidative stress , transplantation , bilirubin , malondialdehyde , antioxidant , reactive oxygen species , endocrinology , medicine , superoxide dismutase , glutathione peroxidase , diabetes mellitus , chemistry , biochemistry
Islet transplantation is a promising option for the treatment of type 1 diabetes. However, the current lack of practical techniques for the isolated islets preservation still hampers the advancement of life-saving islet transplantation. Islet suffers from internal or external stimuli-induced oxidative stress and subsequent inflammation during preservation, which leads to disappointing outcomes regarding islet yield, survival, and function. Reactive oxygen species (ROS) overproduction is the primary cause of oxidative stress that induces islet loss and dysfunction. Thus, in this article, we hypothesized that an endogenous antioxidant, bilirubin, that could efficiently scavenge ROS and inhibit inflammatory reactions could be beneficial for islet preservation.