Open AccessDonor PNPLA3 and TM6SF2 Variant Alleles Confer Additive Risks for Graft Steatosis After Liver Transplantation
Author(s) -
Irena Míková,
Magdaléeřoldová,
Jaroslav Hubáček,
Dana Dlouhá,
M Jirsa,
Eva Honsová,
Eva Sticová,
Věra Lánská,
Julius Špičák,
Pavel Trunečka
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002876
Subject(s) - liver transplantation , steatosis , allele , odds ratio , medicine , nonalcoholic fatty liver disease , gastroenterology , genotype , transplantation , body mass index , fatty liver , endocrinology , genetics , biology , gene , disease
The rs58542926 polymorphism in transmembrane 6 superfamily member 2 (TM6SF2) is a genetic factor predisposing to nonalcoholic fatty liver disease. We aimed to explore the effect of recipient and donor TM6SF2 rs58542926 genotypes on liver graft fat content after liver transplantation.