Open AccessThe Role of miR-200b-3p in Modulating TGF-β1–induced Injury in Human Bronchial Epithelial Cells
Author(s) -
Shameem Ladak,
Eliott Roebuck,
Jason Powell,
Andrew J. Fisher,
Chris Ward,
Simi Ali
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002845
Subject(s) - transfection , microrna , epithelial–mesenchymal transition , epithelium , respiratory epithelium , in situ hybridization , transforming growth factor , downregulation and upregulation , biology , cancer research , a549 cell , small interfering rna , cell culture , cell , microbiology and biotechnology , pathology , messenger rna , medicine , gene , biochemistry , genetics
Dysregulation of microRNAs (miRNAs) has been implicated in airway diseases where transforming growth factor-β (TGF-β)-induced epithelial-mesenchymal transition (EMT) may contribute to pathophysiology. Our study investigated the role of miRNA-200b in TGF-β1-induced EMT in human bronchial epithelial cells.