Open AccessDiabetogenic Effects of Immunosuppression: An Integrative Analysis
Author(s) -
Mamatha Bhat,
Elisa Pasini,
Aninditee Das,
Cristina Baciu,
Marc Angeli,
Atul Humar,
Kymberly D. Watt,
Johane P. Allard
Publication year - 2020
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002815
Subject(s) - immunosuppression , metformin , diabetes mellitus , context (archaeology) , insulin , medicine , biology , endocrinology , paleontology
Posttransplant diabetes mellitus (PTDM) affects up to 50% of solid organ transplant recipients and compromises long-term outcomes. The goal of this study was to investigate how immunosuppressants affect gene expression in a manner that increases diabetes risk, by performing integrative analysis on publicly available, high-throughput gene expression data.