Open AccessLife-supporting Kidney Xenotransplantation From Genetically Engineered Pigs in Baboons: A Comparison of Two Immunosuppressive Regimens
Author(s) -
Takayuki Yamamoto,
Hidetaka Hara,
Jeremy B. Foote,
Liaoran Wang,
Qi Li,
Edwin Klein,
Schuurman Hj,
Hongmin Zhou,
Juan Li,
A. Joseph Tector,
Zhongqiang Zhang,
Mohamed Ezzelarab,
Ray Lovingood,
David Ayares,
Devin E. Eckhoff,
David K. C. Cooper,
Hayato Iwase
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002796
Subject(s) - xenotransplantation , tacrolimus , medicine , kidney , miniature swine , immunosuppression , eculizumab , immunology , transplantation , gastroenterology , immune system , complement system
The aims of this study were to evaluate the efficacy of US Food and Drug Administration-approved drugs in genetically engineered pig-to-baboon kidney xenotransplantation and compare the results with those using an anti-CD40 monoclonal antibody (mAb)-based regimen.