Open AccessChanges of T-cell Immunity Over a Lifetime
Author(s) -
Yeqi Nian,
Koichiro Minami,
Ryoichi Maenesono,
Jasper Iske,
Jin Yang,
Haruhito Azuma,
Abdala Elkhal,
Stefan G. Tullius
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002786
Subject(s) - immunosuppression , immunity , immunology , biology , t cell , cellular immunity , immune system , phenotype , function (biology) , medicine , microbiology and biotechnology , genetics , gene
T-cell immunity undergoes a complex and continuous remodeling with aging. Understanding those dynamics is essential in refining immunosuppression. Aging is linked to phenotypic and metabolic changes in T-cell immunity, many resulting into impaired function and compromised effectiveness. Those changes may impact clinical immunosuppression with evidences suggesting age-specific efficacies of some (CNI and mammalian target of rapamycin inhibitors) but not necessarily all immunosuppressants. Metabolic changes of T cells with aging have only recently been appreciated and may provide novel ways of immunosuppression. Here, we provide an update on changes of T-cell immunity in aging.