Open AccessMHC-mismatched Allotransplantation of Induced Pluripotent Stem Cell-derived Cardiomyocyte Sheets to Improve Cardiac Function in a Primate Ischemic Cardiomyopathy Model
Author(s) -
Noriyuki Koibuchi,
Shigeru Miyagawa,
Satsuki Fukushima,
Takuji Kawamura,
Akira Kawamura,
Shohei Yoshida,
Seiko Eiraku,
Akira Harada,
Keiko Matsunaga,
Tadashi Watabe,
Köichi Toda,
Jun Hatazawa,
Yoshiki Sawa
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002765
Subject(s) - induced pluripotent stem cell , major histocompatibility complex , transplantation , mhc class i , biology , immune system , immunology , medicine , embryonic stem cell , genetics , gene
Although allogeneic-induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) exhibit potential in cardiomyogenesis for heart failure, whether major histocompatibility complex (MHC)-matched allogenic iPSC implantation (MMAI) minimizes immune rejection for cell survival or functional recovery remains unknown. We herein explored whether MMAI with an iPSC-CM sheet is stable for a longer period and therapeutically more effective than MHC-mismatched AI in a primate ischemic cardiomyopathy model.