Open AccessPituitary Adenylate Cyclase-activating Polypeptides Prevent Hepatocyte Damage by Promoting Yes-associated Protein in Liver Ischemia-Reperfusion Injury
Author(s) -
Yuan Liu,
Tianfei Lu,
Cheng Zhang,
Zhengze Xue,
Jin Xu,
Ronald W. Busuttil,
Qiang Xia,
Ning Xu,
Jerzy W. KupiecWeglinski,
Hongxiu Ji
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002742
Subject(s) - creb , hepatoprotection , endocrinology , medicine , microbiology and biotechnology , hepatocyte , liver regeneration , biology , regeneration (biology) , transcription factor , biochemistry , in vitro , glutathione , gene , enzyme
Hepatic ischemia-reperfusion injury (IRI) is a severe complication in liver transplantation, hepatectomy, and hemorrhagic shock. As neuropeptides transmit the regulatory signal between nervous and immune systems communication, our previous study documented that pituitary adenylate cyclase-activating polypeptides (PACAP) depressed hepatic Toll-like receptor 4 immune response in liver IRI.