Open AccessChimerism, Transplant Tolerance, and Beyond
Author(s) -
Franka Messner,
Joanna W. Etra,
Jeffrey M. Doddo,
Gerald Brandacher
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002711
Subject(s) - clinical trial , intensive care medicine , nonhuman primate , medicine , transplantation , immune tolerance , computer science , immunology , biology , immune system , pathology , evolutionary biology
The present review discusses current developments in tolerance induction for solid organ transplantation with a particular emphasis on chimerism-based approaches. It explains the basic mechanisms of chimerism-based tolerance and provides an update on ongoing clinical tolerance trials. The concept of "delayed tolerance" is presented, and ongoing preclinical studies in the nonhuman primate setting-including current limitations and hurdles regarding this approach-are illustrated. In addition, a brief overview and update on cell-based tolerogenic clinical trials is provided. In a critical approach, advantages, limitations, and potential implications for the future of these different regimens are discussed.