Open AccessAerosolization of Second-generation Triazoles: In Vitro Evaluation and Application in Therapy of Invasive Airway Aspergillosis
Author(s) -
Harisudhan Thanukrishnan,
Timothy E. Corcoran,
Carlo J. Iasella,
Cody A. Moore,
Joseph A. Nero,
Matthew R. Morrell,
John F. McDyer,
Shahid Hussain,
M. Hong Nguyen,
Raman Venkataramanan,
Christopher R. Ensor
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002697
Subject(s) - voriconazole , medicine , posaconazole , aerosolization , aspergillosis , galactomannan , caspofungin , aspergillus fumigatus , regimen , bronchoalveolar lavage , gastroenterology , surgery , lung , anesthesia , inhalation , antifungal , immunology , dermatology
A lung transplant patient with invasive aspergillosis (IA) manifested symptoms of voriconazole-induced transaminitis with systemic voriconazole and progression of IA after switching to oral posaconazole. With limited options for standard triazole therapy, aerosolized delivery with one of the second-generation triazoles was considered.